Professionials\u27 perceived qualities for collaborative parent and professional partnerships

To truly appreciate and address the strengths and needs of children with disabilities, parents and professionals must be able to work collaboratively within longterm partnerships. Challenging the creation of parent and professional partnerships is a lack of common understanding or agreement upon what relationship qualities facilitate or deter from their development and preservation. This study investigated what relationship qualities are considered necessary according to a select group of professionals to foster collaborative partnerships between professionals and parents as well as to improve their handling of conflict. The study found that relationship qualities such as communication, respect, honesty, trust, flexibility, and confidence were believed essential by professionals for collaborative partnerships to exist. In addition, the professionals attributed these qualities as being critical for conflict prevention. This study also explored expectations professionals held for parents, relationship-building strategies, conflict prevention strategies, and conflict-resolution strategies. The study found that the relationship qualities identified as important for collaborative partnerships and conflict prevention were reflected within the strategies for relationship-building and addressing conflict. However, the relationship qualities for conflict resolution were less apparent within the strategies identified for conflict resolution. This study provides a beginning for parents and professionals to explore the values they bring to partnerships and whether they are demonstrating congruency between their values and actions. The professionals in this study believed that in collaborative partnerships, parents and professionals engage in open and honest communication, take responsibility to work together as a team across home and school environments, share common goals, and engage in mutual childcentered decision-making in order to move children forward and create positive student outcomes. Additional research is still needed to support the findings of this study and to gain the perspectives of parents and professionals representing different cultures and regions and other local systems of special education. Future research should continue to strive for a balance between the perspectives of parents and professionals and to focus on creating additional clarity regarding the meanings of mutually agreed upon relationship qualities as well as factors that indicate the presence of these factors

Altitudinal effects on life history parameters in populations of Liolaemus pictus argentinus (Sauria: Liolaemidae)

We used skeletochronology to assess the age structure, body size and sexual maturity in two populations of Liolaemus pictus argentinus from San Carlos de Bariloche, Argentina. The species occupies a wide altitudinal range within the Patagonian Lake District which enabled us to choose populations from two climatic extremes: 771 m a.s.l. and 1615-1769 m a.s.l. Age of sexual maturity in both populations of L. p. argentinus is achieved with a minimum body size of 49 mm. However, at the high-altitude site, lizards matured between the ages of three to six years and had a lifespan of eight years limiting some individual’s reproductive life to only two years. Lizards from the low-altitude site achieved maturity at the age of four and lived until the age of nine years old. Despite the environmental variations between sites populations’ growth curves’ patterns were similar represented by a rapid initial growth rate of 10.3 mm/year in youngest juvenile which slowed considerably to 4.9 mm/year after attaining sexual maturity, as energy is reallocated towards reproduction, to finally grow at a rate of 0.1 mm/year in the oldest adults. Present results show intraspecific differences in L. pictus, whether it results from adaptive polymorphism or physiological plasticity remains uncertain

Hybrid Dissemination: Adding Determinism to Probabilistic Multicasting in Large-Scale P2P Systems

Abstract. Epidemic protocols have demonstrated remarkable scalability and robustness in disseminating information on internet-scale, dynamic P2P systems. However, popular instances of such protocols suffer from a number of significant drawbacks, such as increased message overhead in push-based systems, or low dissemination speed in pull-based ones. In this paper we study push-based epidemic dissemination algorithms, in terms of hit ratio, communication overhead, dissemination speed, and resilience to failures and node churn. We devise a hybrid push-based dissemination algorithm, combining probabilistic with deterministic properties, which limits message overhead to an order of magnitude lower than that of the purely probabilistic dissemination model, while retaining strong probabilistic guarantees for complete dissemination of messages. Our extensive experimentation shows that our proposed algorithm outperforms that model both in static and dynamic network scenarios, as well as in the face of large-scale catastrophic failures. Moreover, the proposed algorithm distributes the dissemination load uniformly on all participating nodes. Keywords: Epidemic/Gossip protocols, Information Dissemination, Peer-to-Peer

S7A:6 Baseline serum levels of baff or april are independent predictors of sledai response after 12 months of treatment with belimumab in patients with refractory systemic lupus erythematosus

Background Belimumab, a monoclonal antibody targeting BlyS (B lymphocyte stimulator), is used in refractory Systemic Lupus Erythematosus (SLE). Pivotal clinical trials showed that SLE patients with positive anti-dsDNA antibodies and reduced levels of C3 and/or C4 fractions were those more likely to be responders to treatment. Our study aims at exploring predictors of response to Belimumab in the post-marketing experience in consecutive SLE patients treated at a single centre. Methods Twenty-one patients received Belimumab intravenously at standard regimen (10 mg/kg at 0–15–30 days and then every 4 weeks). Anti-dsDNA were tested by Farr assay and C3/C4 levels by nephelometry. Biomarkers belonging to the TNF superfamily and related to B cell activity (BAFF, APRIL, sBCMA, sCD40L, sTACI, TWEAK) were tested by ELISA. All laboratory parameters were tested at baseline and every 6 months afterwards. SLE disease activity was assessed by SLEDAI-2K score. General linear modelling and correlation analysis were performed using SPSS. Results Enrolled patients were 2 males and 19 females with a median (25th-75th percentile) age of 38 (31–42) years. The disease duration at time of Belimumab start was 12 (8–19) years. The baseline SLEDAI score was 6 (4–9), the anti-dsDNA level was 26 (11–99) UI/ml, and their C3 and C4 level was 72 (56–86) and 9 (7–15) mg/dL, respectively. All the parameters of the TNF superfamily showed moderate/strong correlation (r values ranging from 0.543 and 0.989, p In contrast, C3, C4, anti-dsDNA, and SLEDAI were less likely to predict relative SLEDAI change at 12 month of Belimumab treatment (uncontrolled model: C3 p=0.410; C4 p=0.778; anti-dsDNA p=0.412) in this cohort of patients preselected for the treatment with Belimumab. Conclusions In this preselected 'real-life' cohort of refractory SLE patients fulfilling the requirements for Belimumab treatment baseline serum levels of BAFF or APRIL are independent predictors of response to treatment. Therefore, BAFF and APRIL could be useful for response estimation in patients qualifying for Belimumab treatment

Nap sleep spindle correlates of intelligence

Contains fulltext : 152518.pdf (publisher's version ) (Open Access)Sleep spindles are thalamocortical oscillations in non-rapid eye movement (NREM) sleep, that play an important role in sleep-related neuroplasticity and offline information processing. Several studies with full-night sleep recordings have reported a positive association between sleep spindles and fluid intelligence scores, however more recently it has been shown that only few sleep spindle measures correlate with intelligence in females, and none in males. Sleep spindle regulation underlies a circadian rhythm, however the association between spindles and intelligence has not been investigated in daytime nap sleep so far. In a sample of 86 healthy male human subjects, we investigated the correlation between fluid intelligence and sleep spindle parameters in an afternoon nap of 100 minutes. Mean sleep spindle length, amplitude and density were computed for each subject and for each derivation for both slow and fast spindles. A positive association was found between intelligence and slow spindle duration, but not any other sleep spindle parameter. As a positive correlation between intelligence and slow sleep spindle duration in full-night polysomnography has only been reported in females but not males, our results suggest that the association between intelligence and sleep spindles is more complex than previously assumed

CD28null CD4 T-cell expansions in autoimmune disease suggest a link with cytomegalovirus infection

Immunosenescence is thought to contribute to the increase of autoimmune diseases in older people. Immunosenescence is often associated with the presence of an expanded population of CD4 T cells lacking expression of CD28 (CD28null). These highly cytotoxic CD4 T cells were isolated from disease-affected tissues in patients with rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, or other chronic inflammatory diseases and their numbers appeared to be linked to disease severity. However, we recently demonstrated that the common herpes virus, cytomegalovirus (CMV), not ageing, is the major driver of this subset of cytotoxic T cells. In this review, we discuss how CMV might potentiate and exacerbate autoimmune disease through the expansion of CD28null CD4 T cells

Transcriptomics Comparison between Porcine Adipose and Bone Marrow Mesenchymal Stem Cells during In Vitro Osteogenic and Adipogenic Differentiation

Bone-marrow mesenchymal stem cells (BMSC) are considered the gold standard for use in tissue regeneration among mesenchymal stem cells (MSC). The abundance and ease of harvest make the adipose-derived stem cells (ASC) an attractive alternative to BMSC. The aim of the present study was to compare the transcriptome of ASC and BMSC, respectively isolated from subcutaneous adipose tissue and femur of 3 adult pigs, during in vitro osteogenic and adipogenic differentiation for up to four weeks. At 0, 2, 7, and 21 days of differentiation RNA was extracted for microarray analysis. A False Discovery Rate ≤0.05 for overall interactions effect and P<0.001 between comparisons were used to determine differentially expressed genes (DEG). Ingenuity Pathway Analysis and DAVID performed the functional analysis of the DEG. Functional analysis of highest expressed genes in MSC and genes more expressed in MSC vs. fully differentiated tissues indicated low immunity and high angiogenic capacity. Only 64 genes were differentially expressed between ASC and BMSC before differentiation. The functional analysis uncovered a potential larger angiogenic, osteogenic, migration, and neurogenic capacity in BMSC and myogenic capacity in ASC. Less than 200 DEG were uncovered between ASC and BMSC during differentiation. Functional analysis also revealed an overall greater lipid metabolism in ASC, while BMSC had a greater cell growth and proliferation. The time course transcriptomic comparison between differentiation types uncovered <500 DEG necessary to determine cell fate. The functional analysis indicated that osteogenesis had a larger cell proliferation and cytoskeleton organization with a crucial role of G-proteins. Adipogenesis was driven by PPAR signaling and had greater angiogenesis, lipid metabolism, migration, and tumorigenesis capacity. Overall the data indicated that the transcriptome of the two MSC is relatively similar across the conditions studied. In addition, functional analysis data might indicate differences in therapeutic application

2022 EULAR points to consider for remote care in rheumatic and musculoskeletal diseases

Background: Remote care and telehealth have the potential to expand healthcare access, and the COVID-19 pandemic has called for alternative solutions to conventional face-to-face follow-up and monitoring. However, guidance is needed on the integration of telehealth into clinical care of people with rheumatic and musculoskeletal diseases (RMD).  Objective: To develop EULAR points to consider (PtC) for the development, prioritisation and implementation of telehealth for people with RMD.  Methods: A multidisciplinary EULAR task force (TF) of 30 members from 14 European countries was established, and the EULAR standardised operating procedures for development of PtC were followed. A systematic literature review was conducted to support the TF in formulating the PtC. The level of agreement among the TF was established by anonymous online voting.  Results: Four overarching principles and nine PtC were formulated. The use of telehealth should be tailored to patient's needs and preferences. The healthcare team should have adequate equipment and training and have telecommunication skills. Telehealth can be used in screening for RMD as preassessment in the referral process, for disease monitoring and regulation of medication dosages and in some non-pharmacological interventions. People with RMD should be offered training in using telehealth, and barriers should be resolved whenever possible. The level of agreement to each statement ranged from 8.5 to 9.8/10.  Conclusion :The PtC have identified areas where telehealth could improve quality of care and increase healthcare access. Knowing about drivers and barriers of telehealth is a prerequisite to successfully establish remote care approaches in rheumatologic clinical practice

A comparison of two sleep spindle detection methods based on all night averages:individually adjusted vs. fixed frequencies

Sleep spindles are frequently studied for their relationship with state and trait cognitive variables, and they are thought to play an important role in sleep-related memory consolidation. Due to their frequent occurrence in NREM sleep, the detection of sleep spindles is only feasible using automatic algorithms, of which a large number is available. We compared subject averages of the spindle parameters computed by a fixed frequency (11-13 Hz for slow spindles, 13-15 Hz for fast spindles) automatic detection algorithm and the individual adjustment method (IAM), which uses individual frequency bands for sleep spindle detection. Fast spindle duration and amplitude are strongly correlated in the two algorithms, but there is little overlap in fast spindle density and slow spindle parameters in general. The agreement between fixed and manually determined sleep spindle frequencies is limited, especially in case of slow spindles. This is the most likely reason for the poor agreement between the two detection methods in case of slow spindle parameters. Our results suggest that while various algorithms may reliably detect fast spindles, a more sophisticated algorithm primed to individual spindle frequencies is necessary for the detection of slow spindles as well as individual variations in the number of spindles in general